The project will establish a molecular characterization and clustering of TB strains in relation to prevalence, animal-human transmission and resistance to antibiotics. Repeated observational field studies will be conducted in close collaboration with the national tuberculosis program in an African country.

Tuberculosis patients will be offered treatment within the framework of national tuberculosis program.

Livestock carcasses will be collected in abattoir surveys for the cultivation of Mycobacterium tuberculosis complex.

Region-deletion polymerase chain reaction and sequencing of single-nucleotide polymorphism of genes responsible for antibiotic resistance of all isolated TB strains will provide specific information on the evolutionary pathways of TB at the interface between humans and live-stock and between West and East Africa.